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mlh1 promoter methylation analysis  (Pyrosequencing Inc)

 
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    Structured Review

    Pyrosequencing Inc mlh1 promoter methylation analysis
    Representative images of an EC with <t>MLH1</t> deficiency, absence of MLH1 promoter <t>methylation,</t> and positive EPM2 AIP1 immunostaining. The tumor exhibited biallelic somatic alteration of MLH1 ; one pathogenic variant in MLH1 ( NM_000249.4 ): p.Glu633 Ter (c.1897G > T), classified as a stop-gained mutation, truncating the <t>MLH1</t> <t>protein,</t> as well as loss of heterozygosity (LOH) detected in chromosomal region 3p22.2-q27.1
    Mlh1 Promoter Methylation Analysis, supplied by Pyrosequencing Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mlh1 promoter methylation analysis/product/Pyrosequencing Inc
    Average 86 stars, based on 1 article reviews
    mlh1 promoter methylation analysis - by Bioz Stars, 2026-05
    86/100 stars

    Images

    1) Product Images from "EPM2 AIP1 immunohistochemistry as a surrogate of promoter methylation analysis in endometrial carcinoma"

    Article Title: EPM2 AIP1 immunohistochemistry as a surrogate of promoter methylation analysis in endometrial carcinoma

    Journal: Virchows Archiv

    doi: 10.1007/s00428-025-04132-3

    Representative images of an EC with MLH1 deficiency, absence of MLH1 promoter methylation, and positive EPM2 AIP1 immunostaining. The tumor exhibited biallelic somatic alteration of MLH1 ; one pathogenic variant in MLH1 ( NM_000249.4 ): p.Glu633 Ter (c.1897G > T), classified as a stop-gained mutation, truncating the MLH1 protein, as well as loss of heterozygosity (LOH) detected in chromosomal region 3p22.2-q27.1
    Figure Legend Snippet: Representative images of an EC with MLH1 deficiency, absence of MLH1 promoter methylation, and positive EPM2 AIP1 immunostaining. The tumor exhibited biallelic somatic alteration of MLH1 ; one pathogenic variant in MLH1 ( NM_000249.4 ): p.Glu633 Ter (c.1897G > T), classified as a stop-gained mutation, truncating the MLH1 protein, as well as loss of heterozygosity (LOH) detected in chromosomal region 3p22.2-q27.1

    Techniques Used: Methylation, Immunostaining, Variant Assay, Mutagenesis

    Representative images of an EC with MLH1 with a methylation score close to the cut-off. The initial biopsy A showed negative EPM2 AIP1 immunostaining and a methylation score of 9.8. In the surgical specimen B , EPM2 AIP1 immunostaining was negative, but the methylation score increased to 60% after tumor microdissection
    Figure Legend Snippet: Representative images of an EC with MLH1 with a methylation score close to the cut-off. The initial biopsy A showed negative EPM2 AIP1 immunostaining and a methylation score of 9.8. In the surgical specimen B , EPM2 AIP1 immunostaining was negative, but the methylation score increased to 60% after tumor microdissection

    Techniques Used: Methylation, Immunostaining, Laser Capture Microdissection



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    mlh1 promoter methylation analysis  (Pyrosequencing Inc)
    86
    Pyrosequencing Inc mlh1 promoter methylation analysis
    Representative images of an EC with <t>MLH1</t> deficiency, absence of MLH1 promoter <t>methylation,</t> and positive EPM2 AIP1 immunostaining. The tumor exhibited biallelic somatic alteration of MLH1 ; one pathogenic variant in MLH1 ( NM_000249.4 ): p.Glu633 Ter (c.1897G > T), classified as a stop-gained mutation, truncating the <t>MLH1</t> <t>protein,</t> as well as loss of heterozygosity (LOH) detected in chromosomal region 3p22.2-q27.1
    Mlh1 Promoter Methylation Analysis, supplied by Pyrosequencing Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/mlh1 promoter methylation analysis/product/Pyrosequencing Inc
    Average 86 stars, based on 1 article reviews
    mlh1 promoter methylation analysis - by Bioz Stars, 2026-05
    86/100 stars
    		  Buy from Supplier

    Image Search Results


    Representative images of an EC with MLH1 deficiency, absence of MLH1 promoter methylation, and positive EPM2 AIP1 immunostaining. The tumor exhibited biallelic somatic alteration of MLH1 ; one pathogenic variant in MLH1 ( NM_000249.4 ): p.Glu633 Ter (c.1897G > T), classified as a stop-gained mutation, truncating the MLH1 protein, as well as loss of heterozygosity (LOH) detected in chromosomal region 3p22.2-q27.1

    Journal: Virchows Archiv

    Article Title: EPM2 AIP1 immunohistochemistry as a surrogate of promoter methylation analysis in endometrial carcinoma

    doi: 10.1007/s00428-025-04132-3

    Figure Lengend Snippet: Representative images of an EC with MLH1 deficiency, absence of MLH1 promoter methylation, and positive EPM2 AIP1 immunostaining. The tumor exhibited biallelic somatic alteration of MLH1 ; one pathogenic variant in MLH1 ( NM_000249.4 ): p.Glu633 Ter (c.1897G > T), classified as a stop-gained mutation, truncating the MLH1 protein, as well as loss of heterozygosity (LOH) detected in chromosomal region 3p22.2-q27.1

    Article Snippet: In summary, results show concordance between MLH1 promoter methylation analysis by pyrosequencing and EPM2 AIP1 IHC, with 100% EPM2 AIP1 negativity in the 70 cases that exhibited MLH1 promoter methylation by pyrosequencing.

    Techniques: Methylation, Immunostaining, Variant Assay, Mutagenesis

    Representative images of an EC with MLH1 with a methylation score close to the cut-off. The initial biopsy A showed negative EPM2 AIP1 immunostaining and a methylation score of 9.8. In the surgical specimen B , EPM2 AIP1 immunostaining was negative, but the methylation score increased to 60% after tumor microdissection

    Journal: Virchows Archiv

    Article Title: EPM2 AIP1 immunohistochemistry as a surrogate of promoter methylation analysis in endometrial carcinoma

    doi: 10.1007/s00428-025-04132-3

    Figure Lengend Snippet: Representative images of an EC with MLH1 with a methylation score close to the cut-off. The initial biopsy A showed negative EPM2 AIP1 immunostaining and a methylation score of 9.8. In the surgical specimen B , EPM2 AIP1 immunostaining was negative, but the methylation score increased to 60% after tumor microdissection

    Article Snippet: In summary, results show concordance between MLH1 promoter methylation analysis by pyrosequencing and EPM2 AIP1 IHC, with 100% EPM2 AIP1 negativity in the 70 cases that exhibited MLH1 promoter methylation by pyrosequencing.

    Techniques: Methylation, Immunostaining, Laser Capture Microdissection